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Communication breakdown: senescent cells in interorgan communication of aging
Rituparna Ghosh1, Shweta S Dipali2, Gabriela Desdín-Míco3
1Columbia Center for Translational Immunology and Burch-Lodge Center for Human Longevity, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
None:
Cellular senescence is a complex cell fate characterized by stable cell cycle arrest and other heterogeneous changes. Senescent cells play a causal role in aging, although the underlying mechanisms remain under active investigation. In this opinion article, we propose that senescent cells can act as key mediators of interorgan communication of aging. Recent work defines multifaceted mechanisms, including the production of senescence-associated secretory phenotype factors that act to propagate senescence signals to nearby and distant cells, as well as age-related alterations in immune function that drive chronic inflammation, known as 'inflammaging'. Further investigation of these mechanisms could yield improved strategies to target senescent cells and mitigate their effects on systemic aging via interorgan communication of aging.
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