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Related Experiment Video

Updated: Mar 13, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

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Published on: November 20, 2015

Delineating In Vivo T1-Weighted Intensity Profiles Within the Human Insula Cortex Using 7-Tesla MRI.

C Dalby¹, Austin Dibble¹, J Carvalheiro¹

¹School of Psychology & Neuroscience, University of Glasgow, Glasgow, UK.

Human Brain Mapping

|March 11, 2026

Summary

This summary is machine-generated.

This study used 7 Tesla MRI to map the human insula cortex in vivo, revealing distinct signal intensity patterns in its posterior, anterior-inferior, and middle compartments. These findings offer new anatomical insights and support advanced neuroimaging for personalized medicine.

Keywords:

7T R1map myelin T1map T1‐weighted signal cortical depth dependent MRI high‐field imaging insula

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Area of Science:

Neuroimaging
Human Anatomy
Brain Mapping

Background:

The insula cortex is crucial for sensory and cognitive functions, with its detailed anatomy extensively studied ex vivo.
However, in vivo studies of human insula anatomy and its internal parcellation remain limited.

Purpose of the Study:

To delineate in vivo cortical depth intensity profiles within the human insula cortex using 7 Tesla MRI.
To achieve reliable within-insula parcellation at individual and group levels across diverse cohorts.

Main Methods:

Utilized 7 Tesla magnetic resonance imaging (MRI) to analyze cortical depth intensity profiles.
Defined insular regions of interest using brain atlases and confirmed findings with T1Map and R1Map images.
Acquired data from two independent cohorts (n=21 and n=101) across two different sites.

Main Results:

Identified two distinct clusters of high and low signal intensity within the insula.
Delineated three specific compartments: posterior, anterior-inferior, and middle insula, with characteristic T1-weighted signal intensities.
Demonstrated that atlas choice influences the detection of the anterior high T1-weighted cluster.

Conclusions:

Achieved reliable in vivo within-insula parcellation, providing novel anatomical insights.
Highlighted the utility of 7 Tesla MRI for detailed human brain structure analysis.
Suggested potential implications for individualized medicine through precise in vivo neuroimaging.