Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

4.1K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
4.1K
Neuronal Communication01:28

Neuronal Communication

4.1K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
4.1K
Organization of the Brain01:30

Organization of the Brain

3.0K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
3.0K
Neuroplasticity01:01

Neuroplasticity

2.2K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.

Human brain mapping·2026
Same author

Neuromorphic hierarchical modular reservoirs.

Nature communications·2026
Same author

Replicability of multivariate brain-behaviour associations depends on clinical profile.

Communications biology·2026
Same author

A canary in the mind: A single baseline brain scan predicts adolescent depression and anxiety one year later.

medRxiv : the preprint server for health sciences·2026
Same author

Aging and metabolism contribute separately to brain-body health.

PLoS biology·2026
Same author

Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis.

bioRxiv : the preprint server for biology·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
Same journal

Noninvasive decoding of typed sentences from human brain activity.

Nature neuroscience·2026
Same journal

Striatal control of amygdalar acetylcholine release during salience-associated processing.

Nature neuroscience·2026
Same journal

Mitochondrial stress response drives microglial senescence.

Nature neuroscience·2026
Same journal

Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.

Nature neuroscience·2026
Same journal

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.

Nature neuroscience·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

286

Competitive interactions shape mammalian brain network dynamics and computation.

Andrea I Luppi1,2,3,4,5,6,7, Yonatan Sanz Perl8,9,10,11, Jakub Vohryzek8,9,10,11

  • 1Department of Psychiatry and Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK. andrea.luppi@psych.ox.ac.uk.

Nature Neuroscience
|March 12, 2026
PubMed
Summary
This summary is machine-generated.

Brain network architecture balances cooperation and competition, with competitive interactions enhancing subject specificity and computational performance across species. This reveals key principles of mammalian brain organization.

More Related Videos

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

12.4K
Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

57.5K

Related Experiment Videos

Last Updated: Mar 13, 2026

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

286
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

12.4K
Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

57.5K

Area of Science:

  • Neuroscience
  • Computational Biology
  • Systems Neuroscience

Background:

  • The brain's ability to integrate information relies on complex network architectures.
  • Understanding how distributed circuits balance cooperative and competitive interactions is crucial for deciphering brain function.

Purpose of the Study:

  • To investigate the dynamical and computational relevance of cooperative and competitive interactions within the mammalian connectome using whole-brain modeling.
  • To determine how network architecture influences brain activity and computational performance.

Main Methods:

  • Computational whole-brain modeling applied to human, macaque, and mouse connectomes.
  • Analysis of emergent dynamical properties and subject-specific brain activity reproduction.

Main Results:

  • Mammalian brain activity is best reproduced by models combining modular cooperation with diffuse, long-range competition.
  • Competitive interactions preferentially link regions with opposing molecular and structural profiles.
  • Models incorporating competition demonstrate superior subject specificity and fit to brain activity dynamics, with these properties emerging spontaneously.

Conclusions:

  • A balance of cooperative and competitive interactions is fundamental to mammalian brain network architecture and function.
  • Competitive interactions are key to achieving subject-specific brain dynamics and enhanced computational performance.
  • This study establishes a generative link between network structure, dynamics, and computational capabilities in the brain.