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EBNEO Commentary: The LAKANA Trial: Mass Administration of Azithromycin to Infants in Mali Did Not Reduce Mortality

Maya I Brasher1, Monika S Patil1

  • 1Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Houston, USA.

Acta Paediatrica (Oslo, Norway : 1992)
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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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