[Research progress on medicinal plants of genus Lindera and their sesquiterpenoids]

The genus Lindera, a member of the Lauraceae family, comprises numerous species with broad prospects for medicinal and edible use, and has been widely applied in traditional Chinese medicine(TCM). Modern studies show that the key constituents of Lindera plants include flavonoids, alkaloids, terpenoids, and lignans. Among them, sesquiterpenoids exhibit complex structural diversity and diverse skeletons, as well as a broad spectrum of pharmacological activities such as anti-tumor, anti-inflammatory, neuroprotective, and hepatoprotective effects, making them crucial bioactive compounds of this genus. This paper systematically examined the herbal authentication of medicinal Lindera species and reviewed 165 sesquiterpenoids that have been isolated to date, together with their pharmacological activities. These findings highlight the significant potential of sesquiterpenoids in drug discovery and development, offering valuable insights for the optimal utilization and sustainable development of Lindera plant resources.