[Acquired hemophilia A secondary to marginal zone lymphoma]

Acquired hemophilia A (AHA) is a rare but potentially life-threatening disorder characterized by the development of inhibitors against factor VIII. In 30-50 % of cases, AHA is associated with an underlying condition. We present a case of acquired hemophilia A secondary to marginal zone lymphoma. The diagnosis of AHA should raise suspicion for an underlying neoplastic process, prompting a thorough diagnostic workup. Although etiology remains unidentified in approximately half of AHA cases, it is crucial to maintain a high index of suspicion for malignancy, as neoplastic diseases may emerge even after treatment of AHA. The management of acquired hemophilia A consists of three main objectives : control of active bleeding, eradication of the inhibitor, and treatment of the underlying disease.