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Electrochemiluminescent COFs and HOFs as Porous Material Engineering Systems for Bioanalysis and Environmental
Brij Mohan1,2,3, Bakhtiyar Najafov4, Pawan Kumar Sharma5
1Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
Porous organic frameworks, including covalent organic frameworks (COFs) and hydrogen-bonded organic frameworks (HOFs), are advancing electrochemiluminescence (ECL) biosensing. These materials offer enhanced sensitivity, stability, and adaptability for detecting various analytes.
Area of Science:
- Materials Science
- Analytical Chemistry
- Nanotechnology
Background:
- Electrochemiluminescence (ECL) is a sensitive biosensing technique with limitations in stability and material diversity.
- Porous crystalline materials offer potential solutions to enhance ECL performance.
Purpose of the Study:
- To review recent advances in using covalent organic frameworks (COFs) and hydrogen-bonded organic frameworks (HOFs) for ECL sensing.
- To highlight the advantages and applications of COFs and HOFs in ECL biosensing.
Main Methods:
- Review of recent literature on COFs and HOFs in ECL sensing.
- Analysis of material properties, detection mechanisms, and performance improvements.
- Discussion of strategies for signal amplification, selectivity, and stability.
Main Results:
- COFs provide structural robustness and efficient charge transfer for detecting biomolecules, toxins, and pesticides.
- HOFs offer processability and adaptability for detecting pathogens and heavy metal ions.
- Progress in luminophore engineering and nanostructure design has improved ECL sensitivity and stability.
Conclusions:
- COF- and HOF-based ECL systems show significant potential for next-generation biosensing.
- Integration with nanomaterials and data-driven design can further advance ECL technologies.
- These materials are promising for sustainable, point-of-care ECL sensing applications.
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