Exploring cortical excitability modulation to promote cognitive resilience in aging: an rTMS study protocol.

Area of Science:

• Neuroscience
• Gerontology
• Cognitive Psychology

Background:

• Cognitive resilience is crucial for aging well, maintaining independence and quality of life.
• Non-invasive brain stimulation, like repetitive transcranial magnetic stimulation (rTMS), shows potential for enhancing neuroplasticity and cognition in older adults.
• The left dorsolateral prefrontal cortex (DLPFC) is a key area for cognitive control and executive functions.

Purpose of the Study:

• To outline a study protocol investigating high-frequency rTMS over the left DLPFC in healthy older adults.
• To examine the modulation of cortical excitability (CE) and its effects on cognitive and emotional functioning.
• To assess the feasibility, safety, and signal characterization of CE modulation using rTMS.

Main Methods:

• A detailed protocol for high-frequency rTMS application over the left DLPFC is described.
• Cortical excitability (CE) will be measured using motor-evoked potentials (MEPs) via transcranial magnetic stimulation.
• Cognitive and emotional outcomes will be assessed using a comprehensive neuropsychological battery.

Main Results:

• A preliminary feasibility phase with four participants was completed.
• Procedures were refined, and tolerability, safety, and data acquisition reliability were assessed.
• Initial observations inform the design of a larger ongoing trial.

Conclusions:

• The study protocol provides a framework for investigating rTMS-induced CE modulation in older adults.
• The findings will guide the refinement of methods for a larger trial.
• This research aims to enhance cognitive resilience and quality of life in aging populations.