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Identification of two novel TP53 mutations in secondary acute myeloid leukemia following multiple myeloma: a case

Maria Antonia De Francesco1,2, Rossella Ribolla3, Alessandra Sottini1,2

  • 1Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.

Blood Science (Baltimore, Md.)
|March 12, 2026
PubMed
Abstract

No abstract available in PubMed .

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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