A transdisciplinary framework for managing metabolic dysfunction associated steatotic liver disease

Area of Science:

• Integrative medicine
• Metabolic disorders
• Traditional Indian medicine

Background:

• Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern.
• Conventional pharmacological approaches face challenges due to MASLD's complex etiology and comorbidities.
• The limitations of the "lock-and-key" drug paradigm necessitate innovative management strategies.

Purpose of the Study:

• To propose a transdisciplinary framework for MASLD management.
• To integrate holistic principles of traditional medicine with molecular precision of modern biomedicine.
• To explore Ayurveda as a model for this integrated approach.

Main Methods:

• Development of a unified, biologically plausible transdisciplinary approach.
• Incorporation of dual-diagnostic workflows and an integrative decision interface.
• Implementation of a stage-adaptive management algorithm for MASLD care.

Main Results:

• The framework emphasizes personalized strategies combining nutrition, lifestyle, and drug interventions.
• It leverages the molecular precision of biomedicine and systemic effects of phytochemicals.
• The model shifts focus from disease treatment to health restoration and long-term wellness.

Conclusions:

• This transdisciplinary model offers a comprehensive and patient-centered solution for MASLD.
• It addresses the complexity of MASLD by integrating diverse therapeutic modalities.
• Challenges and scopes for this innovative framework are highlighted for future research and application.