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Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Multi-drug-resistant organisms are the main pathogens of surgical-site infection after colorectal surgery: a
Xuexia Yang1, Yinghui Xiong2, Qianqian Ye3
1Department of Infectious Diseases, The Third Xiangya Hospital, Central South University, China.
Objective:
This study aimed to investigate the incidence, disease burden and risk factors of surgical-site infections (SSIs) after colorectal surgery, particularly caused by multi-drug-resistant organism (MDRO) infections, to provide evidence for the control and prevention of SSIs after colorectal surgery.
Methods:
This retrospective study included patients who underwent colorectal surgery at Xiangya Hospital, Central South University, between 2020 and 2021. Univariate and multi-variate analyses were performed to identify risk factors.
Results:
In total, 2297 patients who had undergone colorectal surgery were included, of which 94 experienced SSIs following surgery. Of the 94 patients, 54 had specific pathogens identified. Furthermore, of these 54 patients, 44 were infected with an MDRO. The main pathogen causing SSIs was Escherichia coli, which was isolated from 43 patients. E. coli isolates showed high levels of resistance to cefazolin and cefuroxime but low resistance to imipenem, piperacillin and tazobactam. Low albumin levels before surgery, prior use of antibiotics, pre-operative intensive care unit (ICU) admission, mechanical ventilation, central venous indwelling catheter and blood transfusion were statistically significant risk factors for SSIs. Prior use of antibiotics and blood transfusion were independent risk factors for SSIs. Pre-operative ICU admission, mechanical ventilation and high pre-operative venous blood glucose levels were statistically significant risk factors for MDRO infection, and pre-operative ICU admission was identified as the only independent risk factor.
Conclusion:
MDROs were the most common pathogens of SSIs after colorectal surgery. Prior antibiotic use, blood transfusion and pre-operative ICU admission are key independent risk factors for SSIs and MDRO infections.
Insights
Multi-drug-resistant organism (MDRO) infections are common in surgical-site infections (SSIs) after colorectal surgery. Prior antibiotic use, blood transfusions, and ICU admission are key risk factors for SSIs and MDROs.
Area of Science:
- Infectious Diseases
- Surgical Infections
- Microbiology
Background:
- Surgical-site infections (SSIs) pose a significant threat after colorectal surgery.
- Multi-drug-resistant organisms (MDROs) are increasingly implicated in healthcare-associated infections.
- Understanding risk factors for SSIs and MDROs is crucial for effective prevention strategies.
Purpose of the Study:
- To determine the incidence, burden, and risk factors of SSIs following colorectal surgery.
- To specifically investigate the role of MDROs in colorectal surgery SSIs.
- To provide evidence for improved control and prevention of SSIs.
Main Methods:
- Retrospective study of 2297 patients undergoing colorectal surgery at Xiangya Hospital (2020-2021).
- Univariate and multivariate analyses were employed to identify risk factors for SSIs and MDRO infections.
- Pathogen identification and antibiotic resistance patterns were analyzed for isolated organisms.
Main Results:
- 94 out of 2297 patients developed SSIs; 44 of these were caused by MDROs.
- Escherichia coli was the most common pathogen, exhibiting resistance to certain antibiotics but susceptibility to others like imipenem.
- Significant risk factors for SSIs included low albumin, prior antibiotic use, ICU admission, mechanical ventilation, central venous catheter, and blood transfusion.
- Independent risk factors for SSIs were prior antibiotic use and blood transfusion.
- Independent risk factors for MDRO infections included pre-operative ICU admission, mechanical ventilation, and high glucose levels, with ICU admission being the sole independent factor.
Conclusions:
- MDROs represent a major cause of SSIs in colorectal surgery patients.
- Prior antibiotic use, blood transfusion, and pre-operative ICU admission are identified as critical independent risk factors for both SSIs and MDRO infections.
- These findings underscore the importance of targeted interventions for high-risk patients to mitigate SSI and MDRO development.
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