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Updated: Aug 9, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
Published on: June 23, 2013
Mechanistic Research on the Crosstalk Between Macrophage Polarization and Energy Metabolic Reprogramming in
Rui Zhu1, Jintong Na1, Xinyi Tan1
1State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Targeting Theranostics Research Center of Guangxi Higher Education, Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
Abstract:
Liver cancer is ranked as the sixth most prevalent and the third deadliest cancer worldwide. Macrophages play a crucial role in cancer resistance mechanisms, and the regulation of their polarization state can alter their anti-tumor activity. Additionally, alterations in liver cancer pathways can shift the polarization of macrophages. Inflammatory agents and medications have the potential to alter macrophage polarization, favoring M1 differentiation and enhancing their anti-tumor activity. This review explores metabolic alterations in liver cancer, macrophage polarization processes, and their interconnections in hepatic oncogenesis. It further elaborates on the prospects and challenges of investigating targeted macrophage metabolism for liver cancer treatment. Modulating macrophage metabolic pathways represents a promising therapeutic approach for hepatic carcinoma.
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