Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medication-related osteonecrosis of the jaw: incidence and risk factors in multiple myeloma patients undergoing pre-autologous stem cell transplant dental extractions.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Correlation between head and neck radiologists reporting on extranodal extension detected on radiological imaging: A head and neck cancer international group multinational study.

Oral oncology·2026
Same author

[Analysis of the efficacy and safety of magaldrate granules quadruple therapy in the treatment of <i>Helicobacter pylori</i> infection].

Zhonghua yi xue za zhi·2026
Same author

Radiation-specific Automated Dosimetric dental, Mandible, and maxilla Annotation for Predicting Periodontal Problems (RADMAP): A semi-automated tool for dosimetric oral risk communication and osteoradionecrosis assessment.

medRxiv : the preprint server for health sciences·2025
Same author

Investigation of the Optic Nerve Head Morphology Influence to the Optic Nerve Head Biomechanics - Regional Deformation Analysis.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

[Prognostic analysis of local excision in 153 cases of locally advanced low rectal cancer following neoadjuvant therapy].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
Same journal

Gingival Fibroblast-Driven Osteoimmunology via the IL-33-ILC2-IL-13 Axis.

Journal of dental research·2026
Same journal

Advancing a Global Oral Health Research Agenda.

Journal of dental research·2026
Same journal

YAP/TAZ Drive Oral Leukoplakia Progression and Confer Ferroptosis Vulnerability.

Journal of dental research·2026
Same journal

Multiancestral GWAS of Dental Malocclusion Identifies Multiple Risk Loci.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
04:09

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

8.9K

Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal

M Moharrami1,2,3, E Watson1,2, S Singhal1

  • 1Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Journal of Dental Research
|March 12, 2026
PubMed
Summary
This summary is machine-generated.

Tooth extraction before radiotherapy for head and neck cancer (HNC) does not change overall osteoradionecrosis (ORN) risk. However, individual patient outcomes vary, highlighting the need for personalized treatment strategies.

Keywords:
head and neck cancerjaw diseasesoral surgical proceduresprecision medicineradiation dosagetreatment heterogeneity

More Related Videos

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
07:15

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

7.6K
Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures
09:10

Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures

Published on: August 5, 2021

2.4K

Related Experiment Videos

Last Updated: May 11, 2026

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
04:09

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

8.9K
Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
07:15

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

7.6K
Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures
09:10

Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures

Published on: August 5, 2021

2.4K

Area of Science:

  • Oncology
  • Oral Surgery
  • Radiotherapy

Background:

  • Osteoradionecrosis (ORN) is a significant complication following radiotherapy for head and neck cancer (HNC).
  • The role of prophylactic tooth extraction prior to radiotherapy in mitigating ORN risk is debated.
  • Understanding heterogeneous treatment effects is crucial for personalized patient management.

Purpose of the Study:

  • To determine the average treatment effect (ATE) of preradiotherapy tooth extraction on ORN risk in HNC patients.
  • To estimate the conditional average treatment effect (CATE) to identify patients who benefit or are harmed by this intervention.
  • To identify clinical factors that modify the treatment effect of preradiotherapy tooth extraction.

Main Methods:

  • Retrospective cohort study of 2,466 adult HNC patients treated with curative radiotherapy (2011-2018).
  • Causal survival forest model targeting restricted mean survival time (RMST) with 5-fold cross-validation.
  • Augmented inverse probability weighting (AIPW) for calibration and rank-weighted average treatment effect (RATE) for treatment prioritization.

Main Results:

  • The overall ATE of preradiotherapy extraction on ORN was not statistically significant (-0.26 months).
  • Significant heterogeneous treatment effects (HTE) were observed, with some patients experiencing harm (Q1: -1.47 months RMST difference) and others benefiting (Q4: +0.94 months RMST difference).
  • Eastern Cooperative Oncology Group performance status and periodontal grade were identified as independent modifiers of treatment benefit.

Conclusions:

  • Preradiotherapy tooth extraction does not alter the overall ORN risk in HNC patients.
  • Individualized treatment effects necessitate a move away from a one-size-fits-all approach.
  • Targeted interventions based on patient-specific factors are essential for optimizing outcomes and minimizing ORN risk.