Tithdiverolides A-C, New Terpene Lactones from Tithonia diversifolia
Yuan Wang1, Lei Li2, Ze-Qing Li1
1Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, China.
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Two undescribed sesquiterpene lactones, tithdiverolides A and B (1 and 2), and a rare meroterpene lactone, tithdiverolide C (3), as well as seven known sesquiterpenoids (4-7) and monoterpenoids (8-10), were obtained from Tithonia diversifolia (Asteraceae). Structural identification of these compounds relied on a synergistic combination of spectroscopic and computational methods, including NMR, HRESIMS, GIAO NMR calculations with DP4+ probability analysis, and ECD calculations. Chemically, compounds 1 and 2 were eudesmane and cadinane sesquiterpene lactones, respectively, while compound 3 was a rare meroterpene lactone possessing monoterpenoid-methyl ketone hybrid. Biologically, compound 3 exhibited NO inhibitory activity with an IC50 of 33.5 ± 1.3 µM.
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