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Updated: Mar 13, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018
Myeloid diversity in tumors: Shaped by genes, location, and time
Maria Nogales-Pons1, Mariola Munárriz-Paños1, Teresa Aceña-Gonzalo1
1Cancer Immunity Laboratory, Tumor Biology Program, Spanish National Cancer Research Center (CNIO) , Madrid, Spain.
Abstract:
Myeloid cells are present in neoplastic tissues from the earliest stages of transformation through to fully developed tumors. However, their intrinsic dynamism and plasticity make them difficult to target therapeutically. Emerging technologies are uncovering previously unrecognized cellular states and functions, thus reshaping our understanding of myeloid cell biology beyond their traditional inflammatory roles. This review discusses recent advances in identifying tumor-specific cues, tissue structural components, and the temporal modulation of neutrophil and macrophage programs in tumors, which are influenced by both cell-intrinsic and systemic signals. By integrating molecular, environmental, and time-dependent aspects of myeloid biology, we discuss here our understanding of their functional diversity and inform the development of future cancer therapy strategies.
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