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Related Experiment Video

Updated: Mar 14, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Upconversion-Mediated Phototherapy for Psoriasis Treatment.

Xiaoyu Ji¹, Zhenjia Lin², Ni Ding²

¹PCFM Lab, Guangdong Engineering Technology Research Centre for Functional Biomaterials, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510006, China.

ACS Applied Bio Materials

|March 12, 2026

Summary

Upconversion nanoparticles (UCNPs) offer a novel phototherapy for psoriasis. This treatment switches pro-inflammatory macrophages to an anti-inflammatory state, improving dermatitis without phototoxicity.

Keywords:

IL-23 macrophage phototherapy psoriasis upconversion

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Published on: October 28, 2015

Area of Science:

Immunodermatology
Nanomedicine
Photomedicine

Background:

Psoriasis is a chronic inflammatory skin disease affecting 2-3% globally, with current treatments causing side effects.
Existing therapies for psoriatic dermatitis lack a cure and can lead to infections or phototoxicity.

Purpose of the Study:

To investigate upconversion nanoparticles (UCNPs) for enhanced in vivo phototherapy in psoriasis treatment.
To evaluate the immunomodulatory effects of UCNP-mediated phototherapy on macrophages in psoriasis.

Main Methods:

Utilized upconversion nanoparticles (UCNPs) activated by 808 nm near-infrared (NIR) light for phototherapy.
Analyzed macrophage polarization (M1 to M2) and gene expression changes in response to UCNP phototherapy.
Assessed the therapeutic efficacy and safety of the novel phototherapy in a psoriasis model.

Main Results:

UCNP phototherapy modulated opsin 3, inhibiting pro-inflammatory M1 macrophages and promoting anti-inflammatory M2 macrophages.
Transcriptomic analysis revealed reversal of the IL-23-induced psoriatic phenotype by upregulating M2-related genes.
Significant improvement in psoriasis-like dermatitis was observed without phototoxicity.

Conclusions:

UCNP-mediated phototherapy demonstrates potential for switching macrophages from M1 to M2 phenotypes in psoriasis.
This novel approach offers a promising, safer alternative for treating psoriatic dermatitis.
Further research into UCNPs could lead to advanced phototherapy strategies for chronic inflammatory skin conditions.