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Updated: May 7, 2026
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
Published on: March 8, 2018
ASSOCIATION BETWEEN IRIS MANIPULATION DURING PHACOVITRECTOMY FOR RETINAL DETACHMENT REPAIR AND PROLIFERATIVE
Suraj Bala1,2, Nitesh Mohan1, Andrea Arline1
1Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio; and.
Purpose:
To determine if iris manipulation during phacovitrectomy for retinal detachment repair is associated with the development of proliferative vitreoretinopathy (PVR).
Methods:
Single-center, comparative, retrospective cohort study of 536 eyes who underwent phacovitrectomy for cataract extraction and retinal detachment repair between 2013 and 2024. Eligible eyes had at least 3-month follow-up. Iris manipulation was defined as mechanical pupillary expansion or synechiolysis. Patients with a history of uveitis were excluded. The primary outcome was the development of PVR, and secondary outcomes included the development of other postoperative complications.
Results:
Of the included eyes, 66 were in the iris manipulation group and 470 were in the control group. The average follow-up time was 18.9 ± 16.0 weeks. Among the 34 eyes without baseline PVR in the iris manipulation group, 5 eyes (14.7%) developed PVR. Among the 282 eyes without baseline PVR in the control group, 12 (4.3%) developed PVR. After adjusting for patients who had previous retinal surgery in an additional regression analysis, iris manipulation remained a significant predictor for PVR development (odds ratio 3.64; P = 0.038). There were no significant differences in the odds ratio for the development of the other postoperative complications between the groups.
Conclusion:
Iris manipulation during phacovitrectomy for retinal detachment repair and cataract extraction was significantly associated with development of PVR in the absence of active inflammation, despite a similar profile of other postoperative complications. These findings highlight the potential role of iris trauma in amplifying intraocular inflammation and contributing to PVR pathogenesis.
