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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Reply to: Immune Checkpoint Blockade in Deficient Mismatch Repair/Microsatellite Instability-High Gastric Cancer:

Alberto Giovanni Leone1, Alessandra Raimondi1, Filippo Pietrantonio1

  • 1Alberto Giovanni Leone, MD, Alessandra Raimondi, MD, and Filippo Pietrantonio, MD, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|March 12, 2026
PubMed
Abstract

No abstract available in PubMed .

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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