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Related Concept Videos

Mismatch Repair

Mismatch Repair

Mismatch Repair

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

Overview of DNA Repair

Overview of DNA Repair

Overview of DNA Repair

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

Nucleotide Excision Repair

Nucleotide Excision Repair

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Related Experiment Video

Updated: Mar 14, 2026

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Published on: March 31, 2022

Reply to: Beyond Parametric Assumptions: Unsupervised Methods Enhance DNA Repair Gene Discovery in SMARCAL1

Ninad Oak¹, Wenan Chen¹, Motomi Mori¹

¹Ninad Oak, PhD, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, Wenan Chen, PhD, Division of Computational Biology, Mayo Clinic, Rochester, MN, Motomi Mori, PhD, MBA, Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, Gang Wu, PhD, Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, Kim E. Nichols, MD, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, Richa Sharma, MD, Department of Pediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic Children's, Cleaveland, OH.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

|March 12, 2026

Summary

No abstract available in PubMed .

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Last Updated: Mar 14, 2026

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gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

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