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Forming & maintaining a research network: Emergency medicine pharmacotherapy research network (EMPHARM-NET).

Megan A Rech¹, David E Zimmerman², Gavin T Howington³

¹Department of Veterans Affairs, Center of Innovation for Complex Chronic Healthcare, Edward Hines, Jr. VA Hospital, Hines, IL, USA.

The American Journal of Emergency Medicine

|March 12, 2026

Summary

The EM Pharmacotherapy Research Network (EMPHARM-NET) is a national, pharmacist-led collaboration advancing emergency medicine pharmacotherapy research. This model successfully generates rigorous evidence and fosters collaboration across diverse practice settings.

Keywords:

Emergency medicine Pharmacist Pharmacotherapy Research

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Area of Science:

Pharmacology
Health Services Research
Clinical Pharmacy

Background:

Emergency medicine pharmacists (EMPs) play a crucial role in optimizing medication use within emergency departments (EDs).
Research in emergency medicine (EM) pharmacotherapy has historically been fragmented and limited to single centers.
A need exists for a unified, collaborative approach to advance high-quality research in acute care pharmacotherapy.

Purpose of the Study:

To establish a national, EMP-led collaborative network for emergency medicine pharmacotherapy research.
To unify investigators, foster mentorship, and promote multicenter studies in acute care pharmacotherapy.
To generate generalizable and practice-changing evidence in EM pharmacotherapy.

Main Methods:

The EM Pharmacotherapy Research Network (EMPHARM-NET) was established in 2019 as a grassroots, volunteer-driven initiative.
The network connects over 25 sites and 50 investigators across diverse practice settings.
Multicenter studies are supported by standardized methodologies, shared resources, and inclusive participation.

Main Results:

EMPHARM-NET has successfully completed multiple multicenter investigations since its inception.
The network has produced over a dozen peer-reviewed publications and gained national recognition.
A distributed, pharmacist-led model has proven effective in generating rigorous, practice-changing evidence.

Conclusions:

EMPHARM-NET demonstrates the viability of a pharmacist-led, distributed model for advancing EM pharmacotherapy research.
The network fosters a sustainable culture of mentorship and collaboration, overcoming challenges like limited research time.
Future expansion includes implementation science, pragmatic trials, and health services research to enhance patient outcomes in EM.