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Updated: Mar 14, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
MYRF restrains mesothelial plasticity to protect the lung
Rachel Warren1, Stijn De Langhe1
1Department of Medicine, Division of Pulmonary and Critical Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
None:
In this issue of Developmental Cell, Luna et al.1 identify myelin regulatory factor (MYRF) as a critical determinant of lung mesothelial specification and quiescence. Their study demonstrates that MYRF loss leads to congenital diaphragmatic hernia or a pleuroparenchymal fibroelastosis-like phenotype, revealing the mesothelium as an actively restrained progenitor population.
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