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Updated: Mar 14, 2026
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Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
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The ups and downs of maturing zonated hepatoctyes
Tabea L Stephan1, Pamela A Hoodless2
1Basic and Translational Research, BC Cancer Research Institute, Vancouver, BC V5Z1L3, Canada.
Developmental Cell
|March 12, 2026
Abstract
None:
Current in vitro protocols differentiating hepatocytes fail to activate mature metabolic genes, induce zone-specific phenotypes, and suppress fetal liver signatures. In this issue, Taguchi, Magalhães et al.1 used CRISPR-Cas9 screening in a mouse model of hepatic development to identify Nr1i3 and Nfix as regulators of hepatocyte maturation and zonation.
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