Design and Characterization of Doxepin In-situ Nasal Gel Using Pectin as a Bio-compatible Matrix

The goal of the current study is to formulate a Doxepin hydrochloride ion triggered trans-nasal gel. The developed formulations were evaluated for gel strength, gelation time, viscosity, mucoadhesion strength, ex-vivo drug permeability drug content, and stability. According to the findings, mucoadhesive strength and viscosity increased as pectin and hydroxypropyl methylcellulose (HPMC) K4M concentrations increased, whereas gelation time and the percentage of drug recovery decreased. With 3.5% pectin and 1.5% HPMC, the improved formulation C2F2 demonstrated the greatest drug release of 97.96% via sheep nasal mucosa. The stability study over a period of three months showed no change in viscosity, pH and drug content. The discovered ion-triggered intra nasal formulations shows enhanced locomotor activity and mobility in mice, when used to treat depression.