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Human dorsal root ganglion-based itch subcluster mapping and pathway analysis via single-nucleus RNA sequencing

Tyler C Beck1, Jordan Morningstar2, Stefano Berto3

  • 1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Dermatology, Vanderbilt University Medical Center, Nashville, TN, USA.

The Journal of Investigative Dermatology
|March 12, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
Pruritusdermatologydorsal root gangliondrug repurposingtranscriptomics

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RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...