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Updated: Mar 14, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
HIV reservoir dynamics according to the timing of antiretroviral therapy initiation or modification
Gantner Pierre1, Cheneau Christine2, Kowalczyk Jakub3
1Virology Laboratory, Strasbourg University Hospitals, Strasbourg, France; Strasbourg University, INSERM, UMR-S 1109, F-67000 Strasbourg, France.
Introduction:
HIV reservoir is the main barrier to HIV cure but its size dynamics on antiretroviral therapy (ART) in various clinical settings is poorly characterized.
Methods:
Responders to a dolutegravir-based regimen (DBR) enrolled in the DRONE study were analyzed for longitudinal total HIV DNA and immune activation biomarkers (sCD14, sCD163, IL-6, IP-10).
Results:
Overall, 169 participants were allocated to various groups: ART-naive acute infections (AI, n = 20) or chronic infections (CI, n = 21), and ART-treated individuals in virological success (VS, n = 116) or failure (VF, n = 12). HIV DNA significantly decreased at W48 of successful DBR in the AI (median: -1.3log10copies/million PBMCs), CI (-0.6), and VF (-0.5) groups, but not in the VS group. Activation biomarkers decreased on DBR only for individuals with ongoing HIV replication at baseline.
Conclusion:
Successful DBR was associated with rapid HIV DNA decline in ART-naive and ART-failing individuals but not in the context of ART switch.
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