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NSAIDs-loaded nanocarriers as emerging anticancer therapeutics: Harnessing inflammation-targeted drug delivery to

Mona M Mostafa1, Shaimaa Mosallam1, Mai M Eltaweel2

  • 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, 6(th) of October City, Giza 12585, Egypt.

International Journal of Pharmaceutics
|March 12, 2026
PubMed

Insights

Chronic inflammation drives cancer progression. Nonsteroidal anti-inflammatory drugs (NSAIDs) show anticancer potential, especially when delivered via nanotechnology to improve efficacy and reduce side effects in cancer therapy.

Area of Science:

  • Oncology
  • Inflammation Research
  • Nanotechnology

Background:

  • Chronic inflammation is a key driver in cancer development, affecting tumor growth, spread, and treatment resistance.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) possess anti-cancer properties by modulating inflammatory pathways.

Purpose of the Study:

  • To review the role of inflammation in cancer.
  • To systematically overview the anticancer effects of NSAIDs.
  • To assess nano-delivery systems for NSAIDs in cancer treatment.

Main Methods:

  • Literature review of inflammation in cancer.
  • Systematic review of NSAIDs' anticancer effects.
  • Assessment of preclinical studies on NSAID nano-delivery systems.

Main Results:

  • NSAIDs demonstrate therapeutic promise in oncology by regulating inflammation.
  • NSAID nano-delivery systems can improve bioavailability and target tumor inflammation.
  • Nanotechnology can reduce systemic toxicity associated with NSAIDs.

Conclusions:

  • Combining NSAIDs with nano-delivery systems is a promising strategy for enhancing cancer treatment.
  • Further research is needed to optimize these combined approaches for clinical use.
Keywords:
CancerChronic inflammationDrug repurposingNSAIDsNanotechnologySignaling pathwaysTumor microenvironment

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