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Dynamic Gastrointestinal Simulation Reveals that Short-Term Mango Purée Feeding Modulates (Poly)phenol Metabolism,
Salud Cáceres-Jiménez1, Natalia Molinero2, Carolina Cueva2
1Departamento de Bromatología y Tecnología de los Alimentos, Campus Rabanales, Ed. Darwin-anexo Universidad de Córdoba, 14071 Córdoba, Spain.
Food Research International (Ottawa, Ont.)
|March 12, 2026
Summary
Mango polyphenols significantly boost gut health by increasing beneficial bacteria and producing beneficial compounds like butyric acid during digestion and fermentation. This study highlights mango
Area of Science:
- * Nutritional Science
- * Microbiology
- * Gastroenterology
Background:
- * Dietary polyphenols are extensively metabolized by gut microbiota.
- * Mangoes are rich in (poly)phenols, but their in vivo fate and effects on gut microbiota are not fully understood.
- * Understanding these interactions is crucial for leveraging mangoes' health benefits.
Purpose of the Study:
- * To evaluate the impact of mango (poly)phenols on gut microbiota composition and metabolic activity.
- * To investigate the transformation of mango (poly)phenols during gastrointestinal digestion and colonic fermentation.
- * To assess the influence of mango consumption on short-chain fatty acid (SCFA) production and ammonium levels.
Main Methods:
- * Dynamic gastrointestinal simulator (simgi®) simulating digestion and fermentation.
- * Mango purée feeding with fecal microbiota from healthy donors.
- * UHPLC-HRMS for (poly)phenol analysis, 16S rRNA sequencing for microbial profiling, and SCFA/ammonium determination.
Main Results:
- * Mango (poly)phenols were extensively metabolized in the colon, yielding beneficial compounds like benzoic and cinnamic acids.
- * Total polyphenol content increased significantly during colonic fermentation.
- * Mango feeding increased beneficial bacteria (e.g., Bifidobacterium spp.), butyric acid production, and reduced ammonium levels.
Conclusions:
- * Mango (poly)phenols undergo significant microbial transformation, generating bioactive metabolites.
- * Mango consumption positively modulates gut microbiota composition and enhances metabolic activity.
- * Mangoes promote a healthier gut environment through polyphenol metabolism and beneficial microbial shifts.
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