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Comparative Efficacy and Patient-centered Outcomes of Intraoral Submucosal Zonal Injection Versus Traditional
Yongshu Wang1, Lishuai Shi2,3, Yaochen Zhang4
1Outpatient Department, Hangzhou Xiaoshan Lisu Medical Cosmetology, Hangzhou, 310000, China.
Aesthetic Plastic Surgery
|March 13, 2026
Summary
A novel intraoral submucosal zonal injection technique offers comparable efficacy to traditional extra-oral methods for perioral contour improvement. This new approach significantly enhances patient comfort and satisfaction while reducing adverse events.
Area of Science:
- Aesthetic Medicine
- Dermatology
- Plastic Surgery
Background:
- Intraoral injection techniques are established methods for various treatments.
- A novel intraoral submucosal zonal injection technique has shown therapeutic promise.
- Further validation of this intraoral technique's efficacy and safety is needed.
Purpose of the Study:
- To compare the efficacy and safety of intraoral submucosal zonal injection versus traditional extra-oral injection for perioral contour enhancement.
- To assess the clinical applicability of the novel intraoral technique.
Main Methods:
- A randomized study involving 52 female patients with perioral aging.
- Patients were assigned to either extra-oral injection (Group A) or intraoral submucosal zonal injection (Group B).
- Efficacy was evaluated using photographic analysis, GAIS, WSRS, patient satisfaction, pain scores (VAS), and adverse event monitoring.
Main Results:
- The intraoral technique demonstrated efficacy comparable to the extra-oral method.
- Intraoral injection significantly improved procedural comfort and patient-rated acceptability.
- Reduced VAS pain scores and fewer adverse events were observed with the intraoral technique.
Conclusions:
- Intraoral submucosal zonal injection is a viable alternative for perioral contour improvement.
- This technique offers enhanced patient satisfaction and a lower incidence of adverse reactions compared to extra-oral injections.
- It is particularly suitable for patients seeking comfort and minimal downtime.
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