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Related Concept Videos

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Related Experiment Video

Updated: Mar 14, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Cohort profile: The DIabetes and ST-segment Elevation Myocardial Infarction (DISTEMI) Study.

Clara Möser1,2,3, Katsiaryna Prystupa2,3, Martin Schön1,2,3

  • 1Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

Cardiovascular Diabetology
|March 13, 2026
PubMed
Summary

This study investigates ST-segment elevation myocardial infarction (STEMI) in patients with diabetes and liver disease. It aims to identify risk subtypes and improve prevention strategies for better patient outcomes.

Keywords:
Cardiovascular functionCohort profileDiabetes mellitusEnergy metabolismGlucose toleranceInsulin sensitivityMagnetic resonance imagingMagnetic resonance spectroscopyMyocardial infarctionSteatotic liver disease

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Area of Science:

  • Cardiology
  • Metabolic Diseases
  • Genomics

Background:

  • Type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD) increase STEMI risk and worsen prognosis.
  • Mechanisms, prognostic factors, and risk subtypes in STEMI patients with (pre)diabetes and MASLD remain unclear.

Purpose of the Study:

  • To investigate changes in glycemia and insulin sensitivity after STEMI.
  • To explore relationships between cardiometabolic factors and cardiac function.
  • To identify biomarkers for cardiovascular disease risk stratification.

Main Methods:

  • Prospective longitudinal cohort study (DISTEMI).
  • Comprehensive cardiometabolic phenotyping including oral glucose tolerance tests (OGTT), clamp-tests, and MRI at 2 and 12 months post-STEMI.
  • Multiomic profiling of blood, urine, and stool samples.

Main Results:

  • Currently includes 100 participants, with 29% having type 2 diabetes.
  • Utilizes advanced imaging and multiomics to assess cardiovascular function, tissue-specific insulin sensitivity, and metabolic profiles.
  • Aims to identify novel biomarkers for risk stratification.

Conclusions:

  • The DISTEMI study integrates phenomic and multiomic data.
  • Identifies cardiometabolic STEMI subtypes and outcome predictors.
  • Aims to enhance precision risk stratification and targeted prevention strategies.