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Injectable radiopaque targets for cone-beam CT guided histotripsy.

Katrina L Falk1,2, Michael A Speidel1,2,3, Grace M Minesinger1,3

  • 1Department of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.

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Summary

New radiopaque barium-based targets are safe and effective for preclinical testing of Cone-beam CT (CBCT) guided histotripsy. These injectable targets allow for precise guidance and treatment without affecting the histotripsy treatment zone.

Keywords:
Histotripsybariumcone-beam CTinjectionpreclinicalswine

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Area of Science:

  • Medical Imaging
  • Surgical Technology
  • Biomaterials

Background:

  • Cone-beam CT (CBCT) is being developed as an image guidance technique for histotripsy.
  • A radiopaque, injectable target is needed for preclinical testing of CBCT-guided histotripsy.

Purpose of the Study:

  • To develop and evaluate a percutaneously injectable, radiopaque target for CBCT-guided histotripsy in preclinical settings.
  • To assess the safety, targetability, and impact on treatment zones of barium-based injectates.

Main Methods:

  • Swine livers were injected with barium paste diluted with saline or autologous blood.
  • Post-injection CBCT images analyzed volume, temporal stability, and artifacts.
  • Injected targets were treated with a clinical histotripsy system, comparing treatment zones to controls.

Main Results:

  • Barium-saline and barium-blood injections showed similar volume and intensity, stabilizing after 30 minutes.
  • Image artifacts were none to moderate in most cases.
  • Barium-blood injectates were visible post-treatment but dispersed; barium-saline was not visible. Treatment zones were not significantly altered.

Conclusions:

  • Percutaneously injectable, radiopaque barium-based targets are acutely safe for CBCT-guided histotripsy.
  • These targets are targetable and treatable, without altering histotripsy treatment zone size in vivo.
  • Barium-based injectates show promise for preclinical evaluation of image-guided histotripsy techniques.