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Updated: Mar 14, 2026

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Advancing Stem Cell Bioprinting to Bridge Engineered and Natural Tissue Constructs.

Qi Gu^1,2,3,4

¹Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Advanced Materials (Deerfield Beach, Fla.)

|March 13, 2026

Summary

Stem cells are revolutionizing organ manufacturing by enabling developmentally inspired fabrication. Integrating intrinsic and extrinsic cues with biofabrication precision transforms tissue engineering into predictive, functional organ production.

Keywords:

bioinks functional tissue fabrication self‐organization stem cell bioprinting tissue engineering

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Area of Science:

Biomedical Engineering
Developmental Biology
Regenerative Medicine

Background:

Human organ complexity stems from intricate cell interactions and precise developmental processes.
Current tissue engineering and bioprinting methods struggle to replicate native organ complexity.
Stem cells offer a promising avenue for overcoming limitations in organ manufacturing due to their differentiation and responsiveness.

Purpose of the Study:

To review advancements in stem-cell-based organ manufacturing.
To highlight strategies for developmentally inspired organ fabrication.
To explore the integration of intrinsic and extrinsic approaches for advanced tissue engineering.

Main Methods:

Review of recent stem-cell-based organ manufacturing progress.
Analysis of intrinsic factors: cell-intrinsic genetic networks and self-organization.
Exploration of extrinsic factors: bioink dynamics, microfabrication, and mechanical cues.

Main Results:

Integration of intrinsic and extrinsic approaches provides a foundation for instructive bioprinting and autonomous development.
Developmentally inspired strategies are crucial for complex organ fabrication.
Combining biofabrication precision with developmental biology principles is key.

Conclusions:

Stem-cell-based organ manufacturing is advancing rapidly.
A convergence of instructive bioprinting and autonomous development is emerging.
Tissue engineering is shifting towards predictive, functional organ production.