Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Carbon Skeletons

Carbon Skeletons

Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...

The Extracellular Matrix

The Extracellular Matrix

Structural Protein Function

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...

Introduction to Fibroblasts

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

The Extracellular Matrix

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

Fibrous Proteins

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Scaffold Protein Liprin β-1 (PPFIBP1) and the Intermediate Filament Synemin: Potential New Markers of Lymphatic Endothelial Cells.

Cells·2026

Same author

Piezosurgery-assisted protocol for impacted mandibular third molar removal with 3D facial swelling analysis: a randomized split-mouth clinical trial on post-surgical sequelae.

Clinical oral investigations·2026

Same author

Cryogenic Foaming of Silk Fibroin Composite for Scaffolds in Bone and Periodontal Regeneration.

Journal of functional biomaterials·2026

Same author

Effectiveness of nonsurgical therapy of peri-implant mucositis: A systematic review.

Periodontology 2000·2026

Same author

Management of Periodontal Abscesses and Endodontic-Periodontal Lesions-A Systematic Review.

Journal of clinical periodontology·2026

Same author

Factors affecting the efficacy of nonsurgical therapy of peri-implantitis.

Periodontology 2000·2026

Search research articles

Related Experiment Video

Updated: May 31, 2026

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Published on: December 22, 2010

Different Hyaluronic Acid-Based Formulations Exert Composition-Dependent Effects on Human Fibroblasts and

Caroline Viola Busch^1,2, Giulia Brunello^1,3, Kathrin Becker³

¹Department of Oral Surgery, University Hospital of Düsseldorf, Düsseldorf, Germany.

Journal of Periodontal Research

|March 13, 2026

Summary

Hyaluronic acid (HA) material responses depend on formulation and concentration. Careful selection of formulation and dosage is crucial for successful clinical use of HA-based materials.

Keywords:

cellular proliferation hyaluronic acid octenidine periodontitis therapy polynucleotides wound healing

More Related Videos

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

Published on: October 7, 2015

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

Related Experiment Videos

Last Updated: May 31, 2026

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Published on: December 22, 2010

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

Published on: October 7, 2015

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

Area of Science:

Biomaterials science
Polymer chemistry

Background:

Hyaluronic acid (HA) is a widely used biopolymer in various medical applications.
The physical and chemical properties of HA-based materials influence their biological interactions and efficacy.

Purpose of the Study:

To investigate the composition- and concentration-dependent responses of hyaluronic acid (HA)-based materials.
To highlight the importance of proper formulation and dosage selection for clinical applications of HA.

Main Methods:

Characterization of HA materials with varying compositions and concentrations.
Evaluation of material responses through in vitro and/or in vivo studies (details not provided in abstract).

Main Results:

HA-based materials exhibit distinct responses that are directly influenced by their composition and concentration.
Specific formulation parameters significantly alter material behavior.

Conclusions:

The clinical success of HA-based materials hinges on precise control over formulation and dosage.
Optimized formulation strategies are essential for maximizing therapeutic benefits and ensuring patient safety.