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Successful Treatment of Aplastic Anemia With Eltrombopag During Pregnancy: A Short Report
Sandra M Frey1, Ferras Alashkar1, H Christian Reinhardt1
1Department of Hematology and Stem Cell Transplantation, West German Cancer Center University Hospital Essen, University Duisburg-Essen Essen Germany.
Introduction:
Aplastic anemia (AA) is a rare bone marrow failure syndrome with pancytopenia, mainly due to immune-mediated stem cell destruction. First-line therapy for acquired severe AA ≥ 50 years/non-severe AA (NSAA) requiring treatment is immunosuppressive therapy with horse anti-thymocyte globulin, cyclosporine A (CSA), and eltrombopag (EPAG). In pregnancy, cytopenia may worsen, while therapeutic options are limited.
Results:
We report the first case of a pregnant patient with NSAA/PNH receiving full-dose EPAG (150 mg/d). Counts remained stable, delivery was uneventful, and the child was healthy. Postpartum, EPAG was discontinued, CSA tapered, and transfusion independence achieved.
Conclusion:
EPAG may represent a feasible option in selected pregnancies.
