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Published on: March 6, 2018
Disulfidptosis and androgenic cancers: from molecular mechanisms to clinical applications and future translational
Xueyang Wang1, Juan Zhao1, Qiming Li1
1Gansu University of Chinese Medicine, Lanzhou, China.
Abstract:
Disulfidptosis, a newly discovered form of programmed cell death, has garnered significant attention in tumor biology and reproductive system research in recent years, particularly demonstrating importance in urological cancer studies. Prostate cancer, testicular cancer, and bladder cancer are highly prevalent malignant tumors among men globally. Modern medical research reveals their complex pathogenesis and the limited efficacy of traditional treatments, necessitating the identification of novel therapeutic targets. Disulfidptosis influences tumor cell survival and death by regulating the formation and cleavage of intracellular protein disulfide bonds, highlighting its pivotal role in tumorigenesis and progression. This paper systematically reviews the molecular mechanisms of disulfidptosis, elucidates its regulatory role in male cancer cells-including key regulatory genes and therapeutic target potential-and discusses its application value and challenges as a potential therapeutic target based on clinical research. It aims to deepen understanding of disulfidptosis regulation, provide new insights and strategies for future precision treatment and clinical translation of male cancers, and drive innovation in related therapeutic approaches.
Insights
Disulfidptosis, a programmed cell death type, impacts male cancers by regulating protein disulfide bonds. Understanding its mechanisms offers new therapeutic targets for prostate, testicular, and bladder cancers.
Area of Science:
- Oncology
- Cell Biology
- Reproductive Medicine
Background:
- Disulfidptosis is a novel programmed cell death mechanism.
- It plays a critical role in tumor biology, especially in male urological cancers.
- Current treatments for prostate, testicular, and bladder cancers have limited efficacy.
Purpose of the Study:
- To systematically review the molecular mechanisms of disulfidptosis.
- To elucidate its regulatory role in male cancer cells, including key genes and therapeutic potential.
- To discuss its clinical application value and challenges as a therapeutic target.
Main Methods:
- Systematic literature review of disulfidptosis.
- Analysis of molecular mechanisms regulating protein disulfide bond formation and cleavage.
- Evaluation of disulfidptosis-related genes in male cancers.
- Review of clinical research on disulfidptosis as a therapeutic target.
Main Results:
- Disulfidptosis influences tumor cell survival and death via intracellular protein disulfide bonds.
- Identified key regulatory genes and therapeutic targets within disulfidptosis pathways.
- Highlighted the pivotal role of disulfidptosis in tumorigenesis and progression of male cancers.
Conclusions:
- Disulfidptosis presents a novel therapeutic avenue for male urological cancers.
- Further research can deepen understanding and guide precision treatment strategies.
- Clinical translation of disulfidptosis-targeting therapies holds significant potential for innovation.
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