Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

247
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
247
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

456
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
456
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

832
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
832

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Burden and distribution of multidrug-resistant bacteria among hospitalized patients with cirrhosis: A systematic review and meta-analysis.

Clinics and research in hepatology and gastroenterology·2026
Same author

Chronic kidney disease in cirrhosis: a study of inpatients from a global perspective.

Gut·2026
Same author

Effectiveness of sodium-glucose cotransporter 2 inhibitors in patients with metabolic dysfunction-associated steatotic liver disease: systematic review and meta-analysis of randomized controlled trials.

European journal of gastroenterology & hepatology·2026
Same author

MRI multicomponent relaxometry for liver fibrosis, inflammation, and steatosis in nonalcoholic steatohepatitis: A prospective study.

European journal of radiology·2026
Same author

Blood multiomics reveal a dysregulated lipid mediator-mitochondrial network associated with the outcome of advanced cirrhosis.

Nature communications·2026
Same author

Primary Sclerosing Cholangitis Recurrence After Liver Transplantation: A Systematic Review and Updated Meta-Analysis.

Liver international : official journal of the International Association for the Study of the Liver·2026

Related Experiment Video

Updated: Mar 14, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.7K

Cryptogenic chronic hepatitis: looking for an ideal diagnostic algorithm.

Guilherme Grossi Lopes Cançado1, Aline Coelho Rocha Candolo2, Mateus Jorge Nardelli1

  • 1Instituto Alfa de Gastroenterologia, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Frontiers in Gastroenterology (Lausanne, Switzerland)
|March 13, 2026
PubMed
Summary
This summary is machine-generated.

Cryptogenic chronic hepatitis can now be better diagnosed using a new algorithm that identifies metabolic-dysfunction-associated fatty liver disease (MAFLD) and lysosomal acid lipase deficiency (LAL-D) as key causes, improving patient management.

Keywords:
algorithmcryptogenic cirrhosiscryptogenic hepatitisdiagnosismetabolic associated fatty liver diseasenon-alcoholic fatty liver disease

More Related Videos

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

18.9K
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

5.0K

Related Experiment Videos

Last Updated: Mar 14, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.7K
Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

18.9K
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

5.0K

Area of Science:

  • Hepatology
  • Internal Medicine
  • Gastroenterology

Background:

  • Cryptogenic chronic hepatitis is an increasing cause of liver transplants, representing 5%-15% of chronic liver disease cases.
  • Identifying the underlying etiology of liver disease is crucial for effective patient management and treatment strategies.

Purpose of the Study:

  • To determine the causes of cryptogenic liver disease in a Brazilian cohort.
  • To develop and validate a new diagnostic algorithm for cryptogenic hepatitis, incorporating metabolic-dysfunction-associated fatty liver disease (MAFLD) and lysosomal acid lipase deficiency (LAL-D).

Main Methods:

  • Retrospective analysis of 326 patients with presumed cryptogenic hepatitis.
  • Application of Czaja's algorithm for initial etiological diagnosis.
  • Development of an updated algorithm including MAFLD and LAL-D investigations.
  • Post-hoc analysis of explant histology in liver transplant recipients.

Main Results:

  • The traditional algorithm diagnosed non-alcoholic fatty liver disease in 21.3% and LAL-D in 1% of patients, leaving 53.6% undiagnosed.
  • Incorporating MAFLD into the new algorithm increased the diagnostic rate to 49.1%, reducing the undiagnosed cases by 11.4%.
  • Post-transplant explant analysis revealed non-alcoholic steatohepatitis in 52.5% of patients.

Conclusions:

  • Approximately one-third of patients with presumed cryptogenic liver disease were diagnosed with MAFLD.
  • Lysosomal acid lipase deficiency (LAL-D) should be considered in the etiological investigation of chronic liver disease of unknown origin.
  • The proposed updated diagnostic algorithm enhances diagnostic accuracy for cryptogenic hepatitis, aiding clinical management.