Recent advances in biomaterials for osteosarcoma treatment

Area of Science:

• Biomaterials Science
• Oncology
• Regenerative Medicine

Background:

• Osteosarcoma is an aggressive bone cancer with poor outcomes due to metastasis and drug resistance.
• Current treatments for osteosarcoma have limited efficacy and significant systemic toxicity.
• There is a critical need for advanced therapeutic strategies for osteosarcoma treatment and bone regeneration.

Purpose of the Study:

• To review recent advancements in biomaterials for osteosarcoma therapy and bone regeneration.
• To systematically analyze studies on natural, synthetic, and composite biomaterials in drug delivery, gene therapy, immunotherapy, and bone repair.
• To highlight stimuli-responsive systems and scaffolds integrating antitumor and regenerative functions.

Main Methods:

• Comprehensive literature review of 64 studies published between 2021-2025.
• Classification of biomaterial-based delivery strategies from single carriers to composite platforms.
• Focus on stimuli-responsive and multifunctional biomaterial systems.

Main Results:

• Biomaterials show significant promise in enhancing local osteosarcoma therapy and promoting bone regeneration.
• Diverse biomaterial platforms, including natural, synthetic, and composite types, are being explored.
• Stimuli-responsive and multifunctional scaffolds demonstrate potential for combined antitumor and regenerative effects.

Conclusions:

• Biomaterials represent a promising approach for addressing the dual challenges of osteosarcoma eradication and skeletal reconstruction.
• Emerging biomaterial strategies offer a concise reference for designing integrated therapeutic solutions.
• Interdisciplinary collaboration is essential for translating these advanced biomaterial systems into clinical practice.