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Familial SCA14: A case report with review
Han-Ke Huang1, Chia-Ju Lee1, Wen-Ling Cheng2
1Department of Neurology, Changhua Christian Hospital, Changhua 50006, Taiwan, R.O.C.
Experimental and Therapeutic Medicine
|March 13, 2026
Summary
Spinocerebellar ataxia type 14 (SCA14) in a Han Chinese family is linked to the PRKCG c.424T>G mutation. This genetic finding expands understanding of SCA14
Area of Science:
- Neurogenetics
- Molecular Neurology
Background:
- Spinocerebellar ataxia type 14 (SCA14) is a rare, autosomal dominant neurodegenerative disorder.
- Mutations in the PRKCG gene, encoding protein kinase Cγ (PKCγ), cause SCA14, leading to diverse clinical presentations from pure cerebellar ataxia to complex neurological involvement.
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