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Updated: May 8, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Case Report: rTMS for recurrent major depressive disorder and generalized anxiety disorder comorbid with atrial
Vipul Reddy1, Nadia Frutkin1,2, Abeer Singh1,3
1Division of Clinical Neuromodulation Research, Karma TMS, Palm Springs, CA, United States.
Abstract:
This paper examines the utilization of repetitive transcranial magnetic stimulation (rTMS) to treat recurrent Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) in a patient comorbid with atrial fibrillation (AF), a type of common heart arrhythmia. Symptoms of AF can increase the risk of MDD and GAD, negatively impacting quality of life. Repetitive Transcranial Magnetic Stimulation (rTMS) is an FDA-approved modality for treatment-resistant major depressive disorder (MDD) and has shown promise for off-label treatment of anxiety disorders. Quantitative psychometric questionnaires were administered weekly, using the PHQ-9 (Patient Health Questionnaire-9) and GAD-7 (Generalized Anxiety Disorder-7), which revealed symptom reductions of 55% and 22.2%, respectively.
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