Related Experiment Video

Updated: Mar 14, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.0K

Cannabis Use Disorder Is Associated With Increased Risk of Acute Myocardial Infarction in Adults With Metabolic

Basile Njei1,2,3,4,5, Sarpong Boateng6, Ifeoma Kwentoh7

  • 1Medicine, Yale University School of Medicine, New Haven, USA.

Cureus
|March 13, 2026
PubMed

Insights

Cannabis use disorder (CUD) in patients with metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis increases the risk of acute myocardial infarction (MI). However, CUD did not correlate with higher in-hospital mortality or major adverse cardiovascular events in this population.

Area of Science:

  • Cardiology
  • Hepatology
  • Addiction Medicine

Background:

  • Cannabis use disorder (CUD) and metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis are independently linked to adverse cardiometabolic profiles.
  • Co-occurrence of CUD and MASH cirrhosis raises concerns for potential cardiovascular complications.

Purpose of the Study:

  • To evaluate the association between CUD and acute myocardial infarction (MI) in hospitalized adults with MASH cirrhosis.

Main Methods:

  • Retrospective cross-sectional analysis of the National Inpatient Sample (2016-2020).
  • Inclusion of adult patients hospitalized with MASH cirrhosis.
  • Identification of CUD using ICD-10-CM codes.
  • Multivariable logistic and Poisson regression models to assess associations with acute MI, mortality, MACE, hepatic decompensation, length of stay, and costs.

Main Results:

  • Among 57,754 MASH cirrhosis hospitalizations, 539 involved CUD.
  • CUD was significantly associated with a higher likelihood of acute MI (aOR 2.18; 95% CI 1.30-3.63).
  • No significant associations found between CUD and in-hospital mortality or major adverse cardiovascular events (MACE).
  • CUD associated with lower odds of hepatic decompensation and lower hospitalization costs.

Conclusions:

  • Hospitalized adults with MASH cirrhosis and CUD face an elevated risk of acute MI.
  • CUD was not associated with increased in-hospital mortality or overall MACE in this cohort.
  • Highlights the need for cardiovascular risk assessment and CUD screening in MASH cirrhosis patients.
  • Findings represent associations, not causality, due to observational study design.
Abstract

Keywords:
acute myocardial infarctioncannabis use disorder (cud)cardiovascular outcomescirrhosisin-hospital mortalitymetabolic dysfunction-associated steatohepatitis (mash)

More Related Videos

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K
Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates06:09

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates

Published on: May 30, 2025

877

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.4K
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
1.1K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
793
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
647
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
702
Stress Prevention and Stress Management Techniques IV01:26

Stress Prevention and Stress Management Techniques IV

Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
306