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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Left Atrial Deformation Parameters After Myocardial Infarction With Low Triiodothyronine Syndrome and Their

Edita Jankauskiene1,2, Neda Jonaitiene1, Martynas Jankauskas2

  • 1Department of Cardiology, Lithuanian University of Health Sciences, Kaunas Clinics, 44307 Kaunas, Lithuania.

Cardiology Research
|March 13, 2026
PubMed

Insights

Left atrial strain analysis using speckle-tracking echocardiography predicts adverse outcomes in ST-segment elevation myocardial infarction (STEMI) patients. These parameters, especially in low triiodothyronine (T3) syndrome, improve risk stratification for heart failure and major adverse cardiac events.

Area of Science:

  • Cardiology
  • Echocardiography
  • Thyroidology

Background:

  • Acute myocardial infarction (AMI) management has improved, but long-term complications like heart failure (HF) and atrial fibrillation (AF) persist.
  • Left atrial (LA) function, assessed by speckle-tracking echocardiography (STE), is a sensitive marker of cardiac remodeling.
  • This study investigates the prognostic value of LA deformation parameters in ST-segment elevation myocardial infarction (STEMI) patients, particularly concerning low triiodothyronine (T3) syndrome.

Purpose of the Study:

  • To evaluate the prognostic significance of LA deformation parameters in STEMI patients.
  • To explore the relationship between low T3 syndrome and LA function post-STEMI.
  • To identify predictors of long-term adverse outcomes in STEMI survivors.

Main Methods:

  • Retrospective analysis of 140 first-onset STEMI patients treated with primary percutaneous coronary intervention.
  • Measurement of thyroid hormone concentrations (fT3) within 24 hours of admission, classifying patients into low T3 (n=44) and control (n=96) groups.
  • Echocardiography and STE performed within 72 hours and at 6 months, analyzing LA reservoir strain and strain rate parameters; 10-year follow-up for adverse events.

Main Results:

  • Low T3 patients were older with higher inflammatory markers and reduced acute LA conduit strain rates.
  • After 6 months, LA volume increased more in low T3 patients.
  • Reduced LA reservoir strain and conduit strain rate predicted MACEs and AF, respectively; LA conduit strain rate, LA reservoir strain, LA volume index, and LVEF were independent predictors of adverse outcomes.

Conclusions:

  • STE-derived LA deformation parameters offer valuable prognostic information in post-STEMI patients.
  • LA reservoir strain and conduit strain rate are significant predictors of MACEs and AF.
  • Early STE evaluation enhances risk stratification and guides management for STEMI patients.
Abstract

Keywords:
Left atrial deformationLow T3 syndromeST-segment elevation myocardial infarctionSpeckle-tracking echocardiography

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