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SARM1 Regulates BNIP3-Mediated Mitochondrial Quality Control in Diabetic Hearts

Hina Lateef Nizami1, Keaton E Minor1,2, Patrycja E Szybowska1,2

  • 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation. (H.L.N., K.E.M., P.E.S., I.G., L.B., C.M.L., P.S., C.F.L.).

Circulation Research
|March 13, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
cardiovascular diseasesheart diseaseshyperglycemiamitophagytranscription factors

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Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...