Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Caspases

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Melatonin Alleviates Atrazine-Induced Kidney Damage by Regulating RIPK3 to Inhibit Necroptosis.

Journal of agricultural and food chemistry·2026

Same author

Lycopene Alleviates Deoxynivalenol-Induced Porcine Intestinal Epithelial Barrier Injury by Inhibiting PGAM5-Mediated Mitophagy-Dependent Ferroptosis.

Research (Washington, D.C.)·2026

Same author

Lycopene Antagonizes Deoxynivalenol-Induced Porcine Intestinal Epithelial Cell Senescence by Inhibiting TXNIP-Mediated NLRP3 Inflammasome Activation.

Research (Washington, D.C.)·2026

Same author

Lycopene Prevents DEHP-Induced Ferroptosis in Cerebellar Microglia by Regulating the PEBP1/ALOX15 Axis.

Journal of agricultural and food chemistry·2026

Same author

TOM70-Mitochondrial Pathway Reduction Mediates DEHP-Induced Neuroinflammation in Mice.

Journal of agricultural and food chemistry·2026

Same author

Lycopene Alleviates Atrazine-Induced Mitochondrial Tricarboxylic Acid Cycle Disorder and Associated Cardiac Cell Senescence and Cuproptosis.

Journal of agricultural and food chemistry·2025

Search research articles

Related Experiment Video

Updated: Mar 14, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

Butachlor-Induced BAZ2B Activation Promotes Cardiomyocyte Senescence through cGAS-STING pathway.

Ming Lou¹, Yi-Feng Huang¹, Xin Su¹

¹College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P.R. China.

Journal of Agricultural and Food Chemistry

|March 13, 2026

Summary

This summary is machine-generated.

This study reveals how the herbicide Butachlor causes heart damage by impairing mitochondria and cell growth. Targeting the BAZ2B protein and cGAS-STING pathway may prevent this herbicide-induced cardiotoxicity.

Keywords:

BAZ2B Butachlor Cardiotoxicity Senescence cGAS-STING

More Related Videos

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Published on: February 15, 2021

Related Experiment Videos

Last Updated: Mar 14, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Published on: February 15, 2021

Area of Science:

Environmental toxicology
Molecular biology
Cardiovascular research

Background:

Herbicides like Butachlor are essential in agriculture but pose health risks.
Butachlor (But) overuse can lead to environmental and health issues.
BAZ2B protein impacts cell proliferation and mitochondrial function.

Purpose of the Study:

To investigate the molecular mechanisms of Butachlor-induced cardiotoxicity.
To explore the role of BAZ2B in Butachlor-induced heart damage.

Main Methods:

Examined effects of Butachlor on cardiomyocyte structure and mitochondrial function.
Assessed impact on mitochondrial biogenesis, stress, and unfolded protein response.
Investigated Butachlor's influence on cell proliferation, senescence, BAZ2B expression, and the cGAS-STING pathway.

Main Results:

Butachlor induced cardiomyocyte structural injury and mitochondrial impairment.
Inhibition of mitochondrial biogenesis and induction of mitochondrial stress and unfolded protein response were observed.
Butachlor accelerated cellular senescence, upregulated BAZ2B, and activated the cGAS-STING pathway.

Conclusions:

Butachlor causes cardiotoxicity through mitochondrial dysfunction and cellular senescence.
The BAZ2B protein and cGAS-STING pathway are key mediators in herbicide-induced cardiotoxicity.
Modulating the BAZ2B-mediated cGAS-STING pathway offers a potential therapeutic strategy for preventing Butachlor cardiotoxicity.