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Xenogeneic Collagen-Based Dural Substitute, A Stranger in Sinonasal Pathology
1Anatomic Pathology Division, Department of Pathology, University of California San Diego Health, East Campus Office Building, 9444 Medical Center Drive, La Jolla, CA, 92037, USA.
Abstract:
Sinonasal mesenchymal neoplasms are challenging to classify due to their rarity. Xenogeneic collagen-based dural substitutes, such as DuraMatrix, are used for dural repair in sinonasal surgery, but their histologic features have been described only briefly in a few animal studies. When encountered in sinonasal specimens in the absence of a relevant surgical history, these materials may be mistaken for incidental mesenchymal neoplasms because of features such as intermixed spindle cells and a minimal foreign-body giant cell reaction. By detailing the histopathologic findings, we aim to facilitate recognition of dural substitutes among pathologists and avoid unnecessary diagnostic workup.
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