Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Published on: October 25, 2024

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Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Huan Liu1, Abudureyimujiang Aili2, Zheng Kuang3

  • 1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|March 13, 2026
PubMed
Summary

Very-long-chain ceramides, like Cer24:1, are deficient in severe neutrophilic asthma (NA). Supplementation resolves airway inflammation by targeting the EP2 receptor on T cells, offering a new therapeutic strategy for NA.

Keywords:
Th17 cellsceramideneutrophilic asthmasphingolipids

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