Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

Electrocardiogram

Electrocardiogram

An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...

Electrocardiogram Fundamentals

Electrocardiogram Fundamentals

Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...

Electrophysiology of Normal Cardiac Rhythm

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...

Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The genetic landscape of childhood-onset dystonia in a nationwide Turkish cohort: Clinical spectrum, molecular diagnostics, and therapeutic implications.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2026

Same author

Clinical, Radiological, and Prognostic Features of Pediatric Clinically Isolated Syndrome and Risk of Conversion to Multiple Sclerosis: A Single-center Cohort Study.

Neuropediatrics·2026

Same author

Neonatal-onset genetic epilepsies: Insights from a large multicentre cohort.

Seizure·2026

Same author

The efficacy and tolerability of lacosamide adjunctive therapy in children with drug-refractory epilepsy: A nationwide Turkish cohort study.

Epilepsy & behavior : E&B·2026

Same author

Examination of Prenatal, Perinatal, Postnatal and Parental Psychosocial Characteristics Associated With Autism Spectrum Disorder: A Cross-Sectional Case-Control Study.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2026

Same author

Effects of iron replacement on electrocardiogram parameters in breath-holding spells patients with iron deficiency.

BMC pediatrics·2025

Search research articles

Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Electrocardiographic repolarization and conduction abnormalities in pediatric epilepsy.

Çisil Çerçi Kubur¹, Beyhan Cengiz Özyurt², Fatoş Alkan³

¹Celal Bayar University, Faculty of Medicine, Department of Child Neurology, Manisa, Turkey.

Epilepsy & Behavior : E&B

|March 13, 2026

Summary

Children with epilepsy show subclinical cardiac electrical differences, including altered atrial conduction and ventricular repolarization, compared to healthy children. These findings suggest potential autonomic modulation related to epilepsy, warranting further research into cardiac outcomes.

Keywords:

Antiseizure medications Cardiac effects Epilepsy Heart rate QTc dispersion Repolarization

More Related Videos

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Related Experiment Videos

Last Updated: Mar 15, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Area of Science:

Pediatric Cardiology
Clinical Electrophysiology
Neurology

Background:

Epilepsy in children can affect various physiological systems.
Subclinical cardiac alterations may be present in pediatric epilepsy.
Understanding these changes is crucial for comprehensive patient care.

Purpose of the Study:

To evaluate subclinical alterations in cardiac conduction and ventricular repolarization in children with epilepsy.
To compare corrected QT dispersion (QTcd), Tpeak-Tend (Tp-e) interval, Tp-e-based ratios, and P-wave dispersion (PWD) between pediatric epilepsy patients and healthy controls.
To explore electrophysiological differences between electrocardiographic recordings from emergency department (ED) and interictal outpatient evaluations.

Main Methods:

A prospective case-control study involving 149 children with epilepsy and 75 healthy controls.
Standardized 12-lead electrocardiography was performed.
Key ECG parameters analyzed included QTcd, Tp-e interval, Tp-e/QTc ratio, and PWD.

Main Results:

Children with epilepsy exhibited significantly longer PR intervals, higher PWD, and increased QTc, QTcd, Tp-e interval, and Tp-e/QTc ratio compared to controls.
Differences in conduction and repolarization parameters were observed between ED and outpatient recordings.
Antiseizure medication therapy did not show a significant association with ECG parameters.

Conclusions:

Children with epilepsy demonstrate subclinical atrial conduction and ventricular repolarization differences.
These findings may indicate autonomic or cardiac electrical modulation linked to epilepsy.
Further prospective studies are needed to correlate these electrophysiological findings with clinical cardiac outcomes.