Enhancing Human Papillomavirus Vaccination Uptake After Loop Electrosurgical Excision Procedure (LEEP) at Colposcopy:...

Area of Science:

• Gynecology
• Oncology
• Vaccinology

Background:

• Adjuvant HPV vaccination post-LEEP shows promise in reducing cervical intraepithelial neoplasia 2+ recurrence.
• High-risk patient populations undergoing LEEP represent a critical window for intervention.

Purpose of the Study:

• To increase HPV vaccination rates by 15% within six months in patients undergoing LEEP.
• To identify patient-reported barriers to HPV vaccination in this cohort.

Main Methods:

• An interrupted time series quality improvement study involving 127 patients aged 24-45 undergoing first LEEP.
• Interventions included nurse-led education and Gardasil-9 prescription provision.
• Primary outcome: vaccination rate at six months; process measures: prescription/brochure distribution; balancing measures: cost, vaccine reactions.

Main Results:

• The HPV vaccination rate increased from 42.5% to 69.3% (26.8% absolute increase) at six months.
• Among patients seen in follow-up, 47.9% initiated the vaccine series.
• Primary barriers to vaccination were cost (32.4%) and time constraints (23.3%).

Conclusions:

• Collaborative interventions effectively increase HPV vaccination rates in patients undergoing LEEP.
• This strategy presents a vital opportunity for cervical cancer prevention engagement.