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A Rare SMARCA4-Deficient Subglottic Adenoid Cystic Carcinoma With Early Pulmonary Metastasis
Ko-Chun Fang1, Fu-Min Fang2,3,4, Shau-Hsuan Li5
1Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Abstract:
This report describes a rare primary subglottic adenoid cystic carcinoma harboring a SMARCA4 loss-of-function mutation, a molecular driver not previously reported in this anatomical site. Despite presenting with locally advanced pT4a disease and early pulmonary metastasis, the patient achieved 5-year local control following total laryngectomy and adjuvant radiotherapy. The findings suggest that molecular profiling can identify non-MYB-driven subtypes and guide individualized management for atypical laryngeal malignancies.
Insights
A rare subglottic cancer with a SMARCA4 mutation was treated successfully. Molecular profiling helps identify rare laryngeal cancer subtypes for personalized treatment.
Area of Science:
- Oncology
- Genetics
Background:
- Adenoid cystic carcinoma (ACC) is a rare cancer.
- Primary subglottic ACC is exceptionally rare.
- SMARCA4 mutations are known drivers in some cancers but not previously reported in subglottic ACC.
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