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Related Experiment Video

Updated: Jun 25, 2026

Investigating the Three-dimensional Flow Separation Induced by a Model Vocal Fold Polyp
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Gene Expression Differences Between Vocal Fold Polyps and Reinke's Edema.

Kamyar Iravani1, Negar Azarpira2, Mahintaj Dara3

  • 1Department of Otolaryngology, Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The Laryngoscope
|March 13, 2026
PubMed
Summary

Gene expression analysis reveals distinct patterns in vocal fold polyps versus Reinke's edema. This research aids in differentiating these benign vocal cord lesions and understanding their underlying causes.

Keywords:
Reinke's edemacollagenfibronectingene expressioninterleukinmatrix metalloproteinasevocal fold polyp

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Area of Science:

  • Otolaryngology
  • Molecular Biology
  • Genetics

Background:

  • Vocal fold polyps and Reinke's edema are benign vocal cord lesions with similar histology but different causes.
  • Accurate diagnosis is challenging due to overlapping histological features.

Purpose of the Study:

  • To investigate gene expression differences between Reinke's edema and vocal fold polyps.
  • To enhance diagnostic capabilities and understand the pathophysiology of these lesions.

Main Methods:

  • A cross-sectional study analyzed intraoperative vocal fold tissue samples.
  • RT-qPCR was used to compare mRNA expression of six key genes (COL1A1, COL3A1, FN1, MMP-9, IL-8, IL-1β).
  • False Discovery Rate (FDR) correction was applied for multiple comparisons.

Main Results:

  • COL1A1, FN1, and MMP-9 were significantly upregulated in vocal fold polyps compared to Reinke's edema (q < 0.01).
  • COL3A1, IL-1β, and IL-8 showed non-significant differences after FDR correction.

Conclusions:

  • Distinct gene expression profiles in inflammation and extracellular matrix genes differentiate vocal fold polyps from Reinke's edema.
  • Findings may facilitate diagnosis and improve understanding of lesion etiology.
  • Further validation with larger sample sizes and healthy controls is recommended.