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Metabolic Bariatric Surgery versus GLP-1 Receptor Agonists for Obesity Management: A Systematic Review and
Lucas Monteiro Delgado1, Gabriel Barone2, Giulia Garcia2
1Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. ldelgado@ufmg.br.
Metabolic and bariatric surgery (MBS) leads to significantly greater weight loss than glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Surgery remains the most effective intervention for severe obesity management.
Area of Science:
- Endocrinology
- Bariatric Surgery
- Pharmacology
Background:
- Obesity management involves metabolic and bariatric surgery (MBS) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs).
- Comparative efficacy of MBS versus GLP-1 RAs for weight loss is not well-established.
Conclusions:
- Metabolic and bariatric surgery achieves superior and more durable weight loss than GLP-1 RA therapy.
- MBS is reaffirmed as the most effective intervention for severe obesity.
- GLP-1 RAs are valuable noninvasive or adjunctive options, but surgery remains the benchmark for sustained outcomes.
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