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Organoids: technology refining, current applications and future directions.

Xianda Cheng1,2, Ziqi Fang2,3, Jianhui Sun4

  • 1College of Life Science, Liaoning University, Shenyang, 110036, China.

Molecular Biomedicine
|March 14, 2026
PubMed
Summary
This summary is machine-generated.

Organoid technology enables precise cancer modeling for drug screening and personalized therapies. These advanced in vitro models are crucial for understanding tumor biology and developing effective cancer treatments.

Keywords:
Immune organoidsImmunotherapyOrganoidsTumorTumor microenvironment

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Area of Science:

  • Biotechnology
  • Cancer Research
  • Stem Cell Biology

Background:

  • Organoids are 3D in vitro models derived from stem cells or tissue cells.
  • They mimic human and mouse organ structures and functions.
  • Organoids have diverse applications, including disease modeling and drug testing.

Purpose of the Study:

  • To review advances in organoid culture and construction methods.
  • To highlight organoid applications in cancer research and treatment.
  • To discuss challenges and future prospects of cancer organoid technology.

Main Methods:

  • Summarizing recent organoid engineering strategies.
  • Reviewing methods for constructing various organoids.
  • Analyzing applications of organoids, particularly immune organoids.

Main Results:

  • Organoids serve as critical platforms for cancer drug screening and targeted therapy.
  • Immune organoids facilitate testing treatment response and drug resistance mechanisms.
  • Organoid models are valuable for angiogenesis and immune microenvironment studies.

Conclusions:

  • Organoids offer a powerful tool for precise cancer modeling.
  • They hold significant potential for in vitro cancer treatment strategies.
  • Further research is needed to address challenges and realize the full prospects of cancer organoids.